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Δ9-Tetrahydrocannabinolic acid synthase: the application of a plant secondary metabolite enzyme in biocatalytic chemical synthesis.

Δ9-Tetrahydrocannabinolic acid synthase (THCAS) from the secondary metabolism of Cannabis sativa L. catalyzes the oxidative formation of an intramolecular C-C bond in cannabigerolic acid (CBGA) to synthesize Δ9-tetrahydrocannabinolic acid (THCA), which is the direct precursor of Δ9-tetrahydrocannabinol (Δ9-THC). Aiming on a biotechnological production of cannabinoids, we investigated the potential of the heterologously produced plant oxidase […]

[Synthetic Cannabinoid Receptor Agonist-Associated Psychotic Disorder: A Case Report].

Synthetic cannabinoid receptor agonists (SCRA) has become one of the most abused substances, recently. JWH-018 street name known as Bonzai is one of the most abused substances in Turkish Republic of Northern Cyprus. The most common symptoms in cases reported with synthetic cannabis use are agitation, angry, paranoia and reference delusions, disorientation, seizure and nausea. […]

Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use.

RATIONALE: Upregulation of α4β2* nicotinic acetylcholine receptors (nAChRs) is one of the most well-established effects of chronic cigarette smoking on the brain. Prior research by our group gave a preliminary indication that cigarette smokers with concomitant use of caffeine or marijuana have altered nAChR availability. OBJECTIVE: We sought to determine if smokers with heavy caffeine […]

[The current aspects of the use of ecstasy/MDMA in France].

Methylenedioxymethamphetamine (MDMA), the active compound of ecstasy, has been used for several years, especially by young adults to benefit of psychostimulant properties. By raising the level of neuromodulators in the synapsis, MDMA can cause psychiatric and physical injuries. After reduced supplies in 2009 (number of ecstasy seizures equal to 10 percent of those recorded in […]

Does cannabidiol have a role in the treatment of schizophrenia?

Schizophrenia is a debilitating psychiatric disorder which places a significant emotional and economic strain on the individual and society-at-large. Unfortunately, currently available therapeutic strategies do not provide adequate relief and some patients are treatment-resistant. In this regard, cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa, has shown significant promise as a potential antipsychotic for the […]

Evaluation of a German version of the Strengthening Families Programme 10-14: a randomised controlled trial.

BACKGROUND: The purpose of this study is to evaluate the effects of a German adaptation of the Strengthening Families Programme 10-14 (SFP 10-14; Familien Stärken). METHODS: A multi-centre randomised controlled trial comparing the German SFP version consisting of seven sessions and four booster-sessions with a minimal intervention on parenting as control condition. Outcomes comprise measures […]

Transient Retinal Dysfunctions after Acute Cannabis Use.

Although cannabis is very widespread worldwide, the impact of cannabis on visual function remains poorly understood. This is partly due to numerous difficulties met in developing clinical studies in cannabis users. Here, we report the first documented case of neuroretinal dysfunction after acute cannabis smoking. This observation was favored by the need of an annual […]

The endocannabinoid system – a target for the treatment of LUTS?

Lower urinary tract symptoms (LUTS) are common in all age groups and both sexes, resulting in tremendous personal suffering and a substantial burden to society. Antimuscarinic drugs are the mainstay of symptom management in patients with LUTS, although their clinical utility is limited by the high prevalence of adverse effects, which often limit patients’ long-term […]

Characteristics of Synthetic Cannabinoid and Cannabis Users Admitted to a Psychiatric Hospital: A Comparative Study.

BACKGROUND: Psychotic and affective exacerbations associated with synthetic cannabinoid (SC) use are becoming an emerging concern in psychiatric hospitals. However, data are lacking regarding whether clinical manifestations of SC use differ from those associated with cannabis use. OBJECTIVE: Our aim was to explore the unique profile of SC users admitted to a mental health center […]

Illicit substance use among persons admitted to probation polyclinic of a regional mental hospital in the Eastern Anatolia, Turkey.

OBJECTIVES: To investigate the illicit substance use trends by gender and year in Eastern Turkey, Elazığ.   METHODS: This is a retrospective study designed to assess the drug use prevalence in persons who admitted to the Probation Policlinic of Elazig Mental Health Hospital between January 2011 and December 2014 in Eastern Turkey, Elazığ. Laboratory screening tests […]

Discrimination, Mental Health, and Substance Use Disorders Among Sexual Minority Populations.

PURPOSE: Sexual minority (lesbian, gay, bisexual) populations have a higher prevalence of mental health and substance use disorders compared to their heterosexual counterparts. Such disparities have been attributed, in part, to minority stressors, including distal stressors such as discrimination. However, few studies have examined associations between discrimination, mental health, and substance use disorders by gender […]

Unusual side effect of cannabis use: acute abdomen due to duodenal perforation.

BACKGROUND: The chronic use of synthetic cannabinoids (SCs) which has become an increasingly prevalent problem can rarely cause gastric and duodenal ulcer because of their effects on gastric secretion and emptying. Since peptic ulcer disease (PUD) is a rarely seen entity in patients who consult to the emergency service with complaints of abdominal pain, most […]

Substance use and criminality among juveniles-under-enquiry in New Delhi.

BACKGROUND: There is an intimate relationship between drugs and criminal behavior. The drug-violence relationship is further complicated by intoxicating doses and/or withdrawal effects of specific drugs. Understanding this relationship is important for both healthcare workers and policy makers. MATERIALS AND METHODS: The study was conducted in Prayas observation home for boys, a short stay home […]

Can smoking initiation contexts predict how adult Aboriginal smokers assess their smoking risks? A cross-sectional study using the 'Smoking Risk Assessment Target'.

OBJECTIVES: Smoking prevalence is slow to reduce among Indigenous Australians of reproductive age. We analysed the relationships between age of smoking initiation, recalled initiation influences and self-assessment of smoking risks in Aboriginal smokers. DESIGN, SETTING AND PARTICIPANTS: A community-based cross-sectional survey of Aboriginal smokers aged 18-45 years (N=121; 58 men) was undertaken, using single-item measures. The […]

Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network.

BACKGROUND: We investigated to what degree environmental exposure (childhood trauma, urbanicity, cannabis use, and discrimination) impacts symptom connectivity using both continuous and categorical measures of psychopathology. METHODS: Outcomes were continuous symptom dimensions of self-reported psychopathology using the Self-report Symptom Checklist-90-R in 3021 participants from The Early Developmental Stages of the Psychopathology (EDSP) study and binary […]

Two new species of Cossinae (Lepidoptera: Cossidae) from Sindh Province of Pakistan.

The Cossidae fauna of Pakistan is still poorly studied, with only a few species reported: Eremocossus foedus (Swinhoe, 1884), Aholcocerus ronkayorum Yakovlev, 2006, Cossulus griseatellus Yakovlev, 2006 and Phragmataecia gurkoi Yakovlev, 2007. The carpenter moths of Zeuzera Latreille, 1804 (Zeuzera sp. and Z. multistrigata Moore, 1881) have been reported in pest management publications from Pakistan […]

Prevalence and correlates of prescription opioid residue injection.

BACKGROUND: There is growing evidence of intravenous administration of prescription opioids (POs) in several countries. Preparation of POs for injection may leave residues in containers and filters used by people who inject drugs and may lead to adverse health outcomes if they are injected. METHODS: This exploratory study used cross-sectional data from the COSMO study, […]

Cannabis consumption patterns among frequent consumers in Uruguay.

BACKGROUND: In 2013, Uruguay became the first country to fully regulate the cannabis market, which now operates under state control. Cannabis can be legally acquired in three ways: growing it for personal use (self-cultivation), cannabis club membership, and from pharmacies (not yet implemented). Users must be entered into a confidential official registry to gain access. […]

The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation.

The cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from Cannabis sativa highlighted by (-)-Δ(9)-tetrahydrocannabinol (THC), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (CB1 or CB2) signaling. Since the initial discovery of THC and related cannabinoids, synthetic and semisynthetic classical cannabinoid analogs have been evaluated to help define […]

Alcohol, Substance Use and Psychosocial Competence of Adolescents in Selected Secondary Schools in Uganda: A Cross Sectional Survey.

AIMS: 1) To determine the nature and extent of alcohol and substance use and 2) To describe the relationship between alcohol use and psychosocial competence among secondary school youths in Northern and Central Uganda. STUDY DESIGN: This was a cross-sectional study. PLACE AND DURATION OF STUDY: Departments of Mental Health, Gulu University (Northern Uganda) and […]

Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives.

INTRODUCTION Neurodegenerative diseases are increasing in parallel to the lengthening of survival. The management of Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD-related disorders, and motor neuron diseases (MND), is mainly targeted to motor and cognitive impairment, with special care for vital functions such as breathing and feeding. AREAS COVERED The present […]

A content analysis of tweets about high-potency marijuana.

INTRODUCTION: “Dabbing” involves heating extremely concentrated forms of marijuana to high temperatures and inhaling the resulting vapor. We studied themes describing the consequences of using highly concentrated marijuana by examining the dabbing-related content on Twitter. METHODS: Tweets containing dabbing-related keywords were collected from 1/1-1/31/2015 (n=206,854). A random sample of 5000 tweets was coded for content […]

Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.

Cannabinoids bind not only to classical receptors (CB1 and CB2) but also to certain orphan receptors (GPR55 and GPR119), ion channels (transient receptor potential vanilloid), and peroxisome proliferator-activated receptors. Cannabinoids are known to modulate a multitude of monoamine receptors. Structurally, there are 3 groups of cannabinoids. Multiple studies, most of which are of moderate to […]

David Casarett's Stoned: A Doctor's Case for Medical Marijuana.

With legal cannabis sales at $5.4 billion in 2015 and expected to rise by another billion this year in the United States, legalization and marijuana’s impact on health is a hot topic of national debate. Casarett, a physician at the University of Pennsylvania, immerses himself in the culture, science, and smoke of medical marijuana in […]

Endocannabinoids in the Gut.

Cannabis has been used medicinally for centuries to treat a variety of disorders, including those associated with the gastrointestinal tract. The discovery of our bodies’ own “cannabis-like molecules” and associated receptors and metabolic machinery – collectively called the endocannabinoid system – enabled investigations into the physiological relevance for the system, and provided the field with […]

Acute Poisonings from Synthetic Cannabinoids – 50 U.S. Toxicology Investigators Consortium Registry Sites, 2010-2015.

Recent reports suggest that acute intoxications by synthetic cannabinoids are increasing in the United States (1,2). Synthetic cannabinoids, which were research compounds in the 1980s, are now produced overseas; the first shipment recognized to contain synthetic cannabinoids was seized at a U.S. border in 2008 (3). Fifteen synthetic cannabinoids are Schedule I controlled substances (3), […]

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

Cannabidiol (CBD) is a major Cannabis sativa constituent, which does not cause the typical marijuana psychoactivity. However, it has been shown to be active in a numerous pharmacological assays, including mice tests for anxiety, obsessive-compulsive disorder, depression and schizophrenia. In human trials the doses of CBD needed to achieve effects in anxiety and schizophrenia are […]

Psychiatric comorbidities in opioid-dependent patients undergoing a replacement therapy programme in Spain: The PROTEUS study.

Opioid-dependent patients show a high rate of psychiatric comorbidities. The prevalence and characteristics of patients with dual diagnosis have not been well established in Spanish opioid agonist treatment (OAT) programmes. Thus, 621 opioid-dependent patients enrolled in OAT programmes were assessed, using the EuropASI questionnaire, for psychiatric comorbidities, which were detected in 67% of patients (anxiety […]

Study: Medical Marijuana Laws Linked To Less Prescription Drug Use, Medicare Spending

The enactment of statewide medicinal cannabis laws is associated with a quantifiable decline in the use of traditional prescription drugs, according to data published in the July edition of the scientific journal Health Affairs. Investigators at the University of Georgia assessed the relationship between medical marijuana legalization laws and physicians’ prescribing patterns in 17 states […]

Cannabis Tinctures 101: What are They, How to Make Them, and How to Use Them

Cannabis tinctures, also known as green or golden dragon, are alcohol-based cannabis extracts – essentially, infused alcohol. In fact, tinctures were the main form of cannabis medicine until the United States enacted cannabis prohibition. With a name like “green dragon,” you might think cannabis tinctures are not for the faint of heart, but they’re actually a great entry point for both recreational and medical users looking to ease into smokeless consumption methods.

How to Dose and Use Cannabis Tinctures

Tincture dosages are easy to self-titrate, or measure. Start with 1mL of your finished tincture and put it under your tongue. If you’re happy with the effects, you’re done. Otherwise, try 2mL the next day and so on until you find the volume you’re happy with (ramp up slowly while testing your desired dosage so you can avoid getting uncomfortably high).

According to The Herbal Medicine-Maker’s Handbook, tinctures will last for many years when stored in a cool, dark location. When combined with easy self-titration, the long shelf life means you can make larger quantities of tinctures at once and have a convenient, accurate way to ingest cannabis.

Compared to the traditional cannabis-infused brownie, tinctures are a low calorie alternative. If you make your tincture with 190-proof alcohol, you’re looking at about 7 calories per mL. Unless you have an extremely weak tincture, you’ll easily stay under your typical brownie’s 112 calorie count (and let’s face it, your brownies are probably far more caloric than that).

Tinctures can be incorporated after cooking into all sorts of meals and drinks:

  • Juices
  • Ice creams and sherbets
  • Soups
  • Gelatin
  • Mashed potatoes and gravy
  • Salad dressing

I recently added some cannabis tincture to my homemade chicken tikka masala for a delicious infused dinner.

How to Make Cannabis Tinctures

If you don’t have a full-featured kitchen or just prefer simple, mess-free preparation techniques, cannabis tinctures are a great DIY project. At a minimum, you can make a tincture with a jar, alcohol, a strainer, and cannabis products. That’s all you need!

Depending on your available time, equipment, and risk tolerance, you’ll prefer some recipes over others. All of the below recipes have been tried by yours truly and have been confirmed to work. Pick whichever one seems most convenient to you!

Traditional Green Dragon

If you’ve heard about green dragon before reading this article, this is probably the recipe you’re most familiar with.

  • Decarboxylate your flower or extract (if you’re using flower, grind it to a fine consistency)
  • Mix your flower or extract in a mason jar with high-proof alcohol (preferably Everclear)
  • Close the jar and let it sit for a few weeks, shaking it once a day
  • After a few weeks, filter it with a coffee grinder and start with a small dose of 1mL to assess potency

    • Master Wu’s Green Dragon

    This guide was first published in 2006 on cannabis.com and is one of the most comprehensive tincture recipes available online, with detailed instructions and excellent tips and tricks. Master Wu’s recipe differs from the traditional method in that it uses heat to speed up the extraction and concentration process. Unlike the traditional method, you’ll be finished with this recipe in an evening. Below you’ll find an abridged summary of the technique.

  • Decarboxylate your flower or extract (if you’re using flower, grind it to a fine consistency)
  • Mix your flower or extract in a mason jar with high-proof alcohol (preferably Everclear)
  • Simmer the jar in a water bath for 20 minutes at 170 degrees F
  • Strain the mixture and store

    • Modern Green Dragon

    If you’re following some of the latest developments in online tincture recipes, you may have heard of the following recipe which sounds too good to be true, but many people (including myself) are having great results with it.

  • Decarboxylate your flower or extract (if you’re using flower, grind it to a fine consistency)
  • Mix your flower or extract in a mason jar with high-proof alcohol (preferably Everclear)
  • Shake for 3 minutes
  • Strain the mixture and store

    • Cannabis Tincture FAQs

    How do I take my tincture?

    Tinctures are usually taken by putting a few drops under your tongue (sublingually). When taken this way, the arterial blood supply under your tongue rapidly absorbs the THC. That being said, you can always swallow the tincture in a drink or food, but it will be absorbed slower by your liver.

    How fast is the onset?

    When dosing a tincture sublingually, expect to feel the effects in 15-45 minutes and reach your peak high at about 90 minutes. If you simply drink the dose, expect a slower onset that more closely resembles traditional edibles.

    How long will I feel the effects?

    Expect to be high longer than when you smoke or vaporize, but shorter than when you eat a butter or oil-based edible.

    Have more questions?

    Ask them in the comments below and we’ll do our best to get them answered for you!

    The Great Wide World of Cannabis Oil and Concentrates

    Cannabis Education and Awareness

    Cannabis Event in Hilo, Hawaii NOTE: This Event has passed. Visit Events page for the latest announcements on upcoming events. Subscribe to Stay Informed ——————————————– June 3rd Doors Open 5pm Starts 5:30pm Hawaii Innovation Center at Hilo   Patient and Caregiver Question and Answer Session with the Presenters Seating Limited $7 tickets in advance – buy […]

    How to Roll a Joint

    The joint is one of the more iconic ways to consume cannabis, and it’s a great way to enjoy the flavor of your flower. Every cannabis smoker should learn how to roll a joint. There are countless opinions on how to create a functional joint, but whatever you do, make sure your creation burns smoothly and evenly.

    To help you hone your own craft, we’ve prepared a simple seven-step guide to successful joint rolling. Begin by gathering supplies (cannabis, papers, and optional crutch/tip material and grinder).

    Step 1: Grind

    Break down your cannabis into shake. If your cannabis is dried well, it should break down easily. A grinder keeps your hand from getting sticky and thus sticking to the joint paper. If you don’t have a grinder, you can grind the herb down by hand, using scissors, or any number of other breakdown methods.

    Step 2: Crutch

    Make a crutch, also called a tip or filter. You can make a crutch out of just about anything, but thin cardboard or business cards are solid go-tos. A lot of joint papers also include crutch material with their packaging. Start with a few “accordion” folds at the end of the cardboard, then roll the material to the desired thickness of your joint. The crutch isn’t absolutely necessary, but it does help keep the shake from falling out of the end or into your mouth as you smoke. It also adds some stability to the joint and allows you to enjoy every bit of cannabis without burning your fingertips.

    Step 3: Fill

    Fill the paper with the shake and the crutch (if you’ve made one). Once the paper has the right amount of shake (a half gram to a gram usually does the trick), you can begin to form and shape the joint with your fingers. (A quick note on papers: There are a lot of different types and flavors of joint papers available. Many people prefer hemp papers because they tend to be thin but strong, and burn evenly without affecting the flavor of the cannabis.)

    Step 4: Pack

    Once you’ve loaded and shaped your joint, it’s time to roll it. Pinch the paper between your fingertips and roll it back and forth between them to pack the cannabis down into its final shape.

    Step 5: Roll

    This step can make or break the quality of your joint. Tuck the unglued side of the paper into the roll and use the glued edge to tack down one end of the paper, using just a little bit of moisture. (Pro tip: Start with the crutch side because it can help guide the paper as it rolls around itself.) Once the paper is tacked on one end, you can work your way down the rest of the seam by tucking and sealing the joint from end to end.

    Step 6: Finish

    Finally, pack the end of the joint to help ensure an even burn. A pen is great, but you can use just about anything. Some good options if you’re on the go: the tip of your shoelace, the drawstring on your hoodie, or a small stick. If you’re not planning on sparking your joint right away, you may want to close the tip with a twist.

    Step 7: Enjoy (and Innovate!)

    There are limitless ways to roll a joint. You can roll them big or small. Get creative! Some people have even transformed joint rolling into an art all on its own, rolling their cannabis into a unique mix of functional origami.

    What’s your favorite way to roll a joint? Share your tips and tricks in the comments below and make sure to teach others this basic cannabis skill!

    Cannabis Event Held in Hilo May 6th, 2016

    Cannabis Event May 6th, 2016

    Gratitude… Coming together over issues affecting patients and caregivers. Creating a larger voice in the legislative process. The Cannabis community in Hawaii helps sufferers of Cannabis-treatable diseases “In our hearts and minds let’s set an intention for all patients and caregivers to be able to safely and affordably obtain a steady supply of high quality medicines.” Last […]

    Cannabis Breeder’s Rights

    Download a free copy of Cannabis Breeder's Rights

    “I don’t want to own my strains. I don’t want to patent it. But my biggest fear is that someone else will take my work and prevent me from working with it. And I see as the only solution to this is to make all of this public domain and open source,” DJ Short, Seattle […]

    Reducing the Health Risks of Smoking Cannabis

    “All drugs pose risks. Whether medicinal or recreational, whether herbal or pharmaceutical, whether legal or illicit, every drug produces undesirable side effects. Cannabis in itself may pose few risks, but inhaling its vape or its smoke can compromise your health. Smoke is the archetypal smoking gun. You might try fooling yourself, but no ploy of smoke and mirrors […]

    Check Out OG Analytical Presents: Cannabis Science Pub

    I came across the following event on Facebook. It sounds very cool. Who doesn’t want to learn more about cannabis science?: OG Analytical presents: Cannabis Science Pub! A FREE monthly educational series on the science of Cannabis. Join OG Analytical every last Tuesday at Cozmic as we explore the science of Cannabis. Play trivia to

    Meet The Man That Discovered The Endocannabinoid System

    I received the following message and thought it was worth passing along: Have you ever heard of the endocannabinoid system? Meet the man who discovered it at #Unity16 March 18-22 in Washington, D.C. ASA is thrilled to announce the Keynote Speaker for the 4th Annual National Medical Cannabis Unity Conference is Professor Lumír Hanuš! Prof.

    10 Cannabis Strains That Won’t Make You (As) Hungry

    “There’s weed that don’t make you hungry? For real? Honey, this changes everything.”

    That was my Lyft driver’s response when I told her not all cannabis makes your gullet an insatiable black hole. Most cannabis consumers – especially first-time experimenters – have only tried high-THC strains, so it’s no wonder that the dispelling of this common misconception comes to the surprise of many who have long associated cannabis with the inevitable “munchies” syndrome.

    The munchies can be a beautiful thing, and I’m not just talking about the pure ecstasy that comes with dual-wielding a fried chicken leg and an ice cream sandwich once in a while. That appetite stimulation is life-changing for patients dealing with cancer, depression, and other gastrointestinal/appetite disorders. But not everyone wants uncontrollable food lust, and some will actively avoid cannabis because of this one side effect – particularly those struggling with pre-existing eating and weight issues.

    For those of you interested in reaping the myriad of benefits cannabis has to offer without the unbridled gluttony, we hope you find this list helpful. Remember, you can click the strain to see if it’s available at a store or dispensary near you!

    High-CBD Strains

    If you’ve ever tried a high-CBD strain before, you’ve probably noticed that they don’t summon the munchies monster like THC-rich varieties. A Yale study published last year found that THC – the same chemical responsible for cannabis’ euphoric high – stimulated a group of nerve cells in the hypothalamus, the area of the brain that governs instincts like hunger and arousal.

    While less is known about CBD’s influence on appetite, we do know that this non-psychoactive constituent counteracts many effects of THC and researchers have even eyed CBD as an anti-obesity treatment based on its activity in the brain. Our own anecdotal evidence leads us to recommend high-CBD, low-THC strains for the best “munchie-less” experience, but a strain with equal parts CBD and THC can also induce less hunger with the added benefit of mild euphoria.

    A popular strain found in many Oregon shops, Harle-Tsu is hybrid cross between two high-CBD parents, Harlequin and Sour Tsunami (which are also worth looking into for minimal munchies strains). Harle-Tsu typically expresses a high-CBD profile with very little THC, making it a perfect choice for anyone who wants the relaxing and therapeutic effects of cannabis minus the euphoria or paranoia.

    The “Remedy” for your over-excited appetite is this indica cross between Cannatonic and Afghan Skunk. With a THC content that rarely squeaks past 1%, Remedy delivers mental tranquility and physical relief without the psychoactive burden. This Pacific Northwest strain is perfect for the patient needing to curb pain, anxiety, tension, headaches, or insomnia, but doesn’t want to interrupt their day with hourly snack breaks.

    Canna-Tsu is taking off across the U.S., discoverable in Oregon, California, Illinois, Washington, Colorado, and many other medical marijuana states. Sweet and earthy in flavor, Canna-Tsu provides a boost to both mood and focus. Though this strain may calm upset tummies, you shouldn’t feel any extra rumblings of hunger.

    For uncompromised energy and clarity, we recommend the low-munchies sativa MediHaze. This one can sometimes exhibit equal levels of THC and CBD, but compared to high-THC, low-CBD strains, MediHaze is much better for keeping the appetite at bay.

    Similar to the widely coveted ACDC hybrid, Cannatonic is a high-CBD strain that relaxes the body while leaving the mind free to focus. On average, Cannatonic has a 2:1 ratio of CBD:THC, meaning you probably won’t feel much in the way of a high or hunger.

    High THCV Sativa Strains

    By now you know what THC and CBD is, but you may not be familiar with the less ubiquitous THCV, a related chemical that suppresses appetite. While most strains on the market today tend to test anywhere between 10-20% THC, what’s considered a high THCV content might only hit a high-water mark of 5%. THCV tends to be more abundant in sativa strains, and it’s possible you’ve noticed that sativas tend to provoke hunger less than indica strains. The unique metabolic effects of THCV even have researchers considering its utility in treating obesity and diabetes.

    [LINK]

    While high-CBD strains tend to induce little to no high, these THCV-rich sativas produce high-energy, psychoactive effects. That’s good news if you like the euphoria associated with cannabis, but don’t want the raging appetite.

    With an average THCV content that ranges between 0.2 to 1.8%, Durban Poison is the perfect weapon against overactive appetites and can be found in most major markets. Cherished for its active, upbeat high that can fuel productivity, this pure African sativa keeps you focused on what matters more than snacks.

    Resist the call of the pizza with Power Plant, an electrifying sativa that descends from African landrace strains. Its spicy, peppery aroma perks up the senses, leaving you with inspiration and positivity instead of a demanding stomach. You can find Power Plant in many different markets across the U.S. and beyond, so check to see if a shop near you is carrying it.

    Kill the temptation to order half Taco Bell’s menu with Jack the Ripper, a sativa strain that carries a tantalizing lemon scent. A favorite in the Pacific Northwest, this invigorating sativa is sure to summon a talkative mood long before a talkative tum.

    Another African sativa, Red Congolese focuses all of its psychoactive energy in the head, helping creativity and focus to thrive. Among the list of activities this sativa motivates, you’ll sooner find hiking, painting, and reading more appealing than eating the entire contents of your fridge. Though most frequently found in Vancouver, BC and Ontario, you might be delightfully surprised by its occasional appearance on the West Coast and in other areas of the U.S..

    As sweet and citrusy as this sativa might taste, Moby Dick doesn’t coerce the appetite as much as other strains. Expect instead to feel your mood and energy elevate to a place in which it’s easy to feel satisfied whether or not you treated yourself to an entire cheesecake. This sativa is lovingly embraced in Canada and Spain, although Americans have also reported sightings of the legendary Moby Dick in many markets.

    Interested in strains that do make you hungry? Try these 10!

    The Scientist

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    Adult Use Initiative Debate

    Originally published by The Emerald Cup on Jan 11, 2016 Frustrated with decades of chaos and a disorganized and fractured community we came together at the 12th Annual Emerald Cup to discuss if there was any point to run an effort with the impending Sean Parker initiative that appears to have the necessary funding. After […]

    Integrated Pest Control and Mold Management

    Hawaii Cannabis Caregivers

    The ecological, economical, and biological sound practices of developing a diverse Integrated Pest Management program to further diminish the use of pesticides and herbicides inside our industry. Resources from Natural Farming Hawaii – Scientifically Proven to Reduce Costs While Growing in Harmony with Nature

    Lab Science and Standards: Myths Facts and Creating a Unified Consensus

    Hawaii Cannabis Organization

    Key questions related to Hawaii’s Controlled Substances Act (329) and Chapter 11-850 of the Hawaii Administrative Rules with respect to required laboratory testing: Is Patient, product and public safety achieved through laboratory testing? Will the testing laws developed by legislators, law enforcement and the Hawaii Department of Health Approved Testing Laboratories detect everything in Cannabis from licensed dispensaries. […]

    Hawaii Medical Marijuana Dispensary License List of Applicants

    Hawaii Cannabis News

    Hawaii State Department of Health (DOH) released the list of applicants for Medical Marijuana Dispensary Licenses. Sixty-six applications were received during the application period of Jan. 12, 2016, 8 a.m., Hawaii Standard Time (HST) to Jan. 29, 2016, 4:30 p.m. HST. The names of all individual applicants and applying entities as well as the county applied for […]

    Oregon Medical Marijuana Program Too Expensive for Patients

    Photo Credit: (Beth Nakamura/The Oregonian)

    “The proposed rules are a direct assault on the (medical marijuana) program and the small family farm,” said Prozanski. Oregon’s medical marijuana advocates say the state’s proposed rules for production impose expensive and unnecessary burdens on growers and will ultimately harm patients who rely on the drug to cope with a wide range of health […]

    Congress Members to VA: Let Veterans Smoke Marijuana

    A group of 21 Senators and Representatives send letter urging VA to permit doctors to discuss and recommend marijuana as a treatment option in states where it’s legal Under the current system, VA doctors are not allowed to give recommendations for patients to receive medical marijuana, even in states that have legalized it. January 27, […]

    Best Practices for Keeping Your Children While Using Medical Cannabis in Hawaii

    Law enforcement will most likely continue their investigation after a routine compliance check if children and what police call, “paraphernalia” were present during the raid. Would you rather risk losing your children to Child Protective Services or treat your disease using Cannabis? There are very few protections and all of them hinge of a police officer’s ability to do […]

    2014 Cannabis Research Study Links

    Cannabis Research http://phoenixtears.ca http://thesethgroup.org http://cannabis-med.org/index.php?lng=en http://gwpharm.com/cannabinoids-science.aspx

    The Difference Between A Marijuana ‘Edible’ And A Cannabis ‘Consumable’

    Marijuana edibles are very popular. I once seen a statisticthat stated 40-50% of all legal marijuana-related product sales in America are of edibles. I wouldn’t be surprised if that number grew in upcoming years. More and more people are either consuming marijuana for the first time now that recreational is legal in some states, or

    Largest Study Ever On Marijuana And Epilepsy Shows Effectiveness Of Cannabis

    Marijuana has been proven to be tremendously effective when it comes to treating epilepsy. It seems like most of the time that I see medical marijuana being talked about on the news or in print media, it’s almost always talking about how CBD can help epilepsy, with countless success stories. There are a lot of

    Every Study Shows Cannabis Works As Medicine For Patients

    When California voters passed Proposition 215 in 1996, the Golden State became the first to legalize medical cannabis in the United States. There was one hitch. No scientific studies and clinical trials demonstrating the effectiveness of cannabis as medicine were available to researchers.

    Some

    “My recommendation was, look, establish a center to study this,” said Grant, who’d previously looked into whether moderate marijuana use causes long-term brain damage (conclusion: it doesn’t).

    “It’ll cost you some money but these studies have not been done before,” he told the legislators.

    Soon, Grant found himself in charge of the new state-funded Center for Medicinal Cannabis Research.

    It was an enviable position. Many scientists in the United States would love to do experiments using pot, but it’s been incredibly difficult to study. The Drug Enforcement Administration lists marijuana as a schedule one drug alongside heroin and ecstasy.

    It’s a category reserved for drugs with “no currently accepted medical use.” Grant said his work challenging that assumption wouldn’t have been possible without Sacramento fully behind him.

    “Without the state of California saying, ‘Yes, we support this work,’ we probably would’ve never gotten federal approval,” Grant said.

    Grant worked with scientists throughout the UC system to complete a series of small human trials. They sourced their samples from the only federally sanctioned grow operation, a pot farm at the University of Mississippi.

    “It would be a joint basically,” Grant said. “But very professionally rolled, I might say. It looked like a cigarette.”.

    The joints all looked and smelled the same, but not all of them got subjects high.

    These studies required placebos, so some joints contained no THC, sort of like the pot version of decaf coffee. Grant had to convince DEA agents these samples would not leave the lab.

    “The DEA has to come locally and say, ‘Where are you going to store it? Let’s look at your research pharmacy,’” Grant said. “In one case they said, ‘Is that safe bolted to the floor?’”

    Subjects smoked their joints in hermetically sealed rooms with no ventilation leading toward non-participants who might unwittingly inhale stray fumes.

    Grant and his colleagues had to jump through lots of regulatory hoops to pull off the experiments. But once they were done, the findings surprised him.

    “I kind of expected, well, we’re going to have a few studies that say yes and a few that will say no, and then at the end of the day we’ll still be arguing,” Grant said. “But in fact every single study showed benefit.”

    Grant said it’s now well-established that cannabis is effective in treating neuropathic pain in patients with diseases like HIV/AIDS. It can reduce spasticity in multiple sclerosis. And — perhaps obviously — it can stimulate appetite in underweight patients.

    Grant said more research is needed before reaching conclusions about marijuana’s usefulness with other diseases, like epilepsy and schizophrenia. He also admits some purported uses have little to no scientific support. But taken altogether, Grant says there’s now more than enough evidence to justify rescheduling marijuana.

    Other scientists agree. The American Academy of Pediatrics recently called for rescheduling. Even U.S. Surgeon General Vivek Murthy has acknowledged marijuana can be helpful in treating certain conditions.

    Alex Kreit, a professor at the Thomas Jefferson School of Law, said learning more about pot will be difficult without rescheduling.

    “It makes it very hard for researchers to get access,” Kreit said. “There are a whole host of hurdles that schedule one drugs come with, as far as research, that schedule two, three and so forth simply don’t have.”

     “It’s completely incongruous that it’s sitting in schedule one with other useless, dangerous drugs.”

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    Study Suggests Cannabis Will Replace Adderall & Ritalin For ADD/ADHD Treatment

    Adderall and Ritalin are DEA Schedule II substances. This means, they have a “high potential for abuse,” can “lead to severe psychological or physical dependence” and are considered “dangerous”

    “When we look at upperclassmen, the number really begins to jump,” says Alan DeSantis, professor of communications at the University of Kentucky who has conducted research on  use in college. “The more time you stay on campus, the more likely you are to use.”

    Two-thirds of college students are offered Adderall and other prescription stimulants by their senior year, and about half of that group (or 31 percent overall) are just saying yes, according to a 2012 study published in the Journal of American College Health.

    Medicinal cannabis is proving to be just as or more effective than common ADD/ADHD prescriptions without the risks and unpleasant side effects.

    The with ADHD who had limited success with conventional treatments for the disorder (Adderall and Ritalin). All 30 reported “improved concentration and sleep” and “reduced impulsivity” after using medicinal cannabis, according to the case report.

    Moreover, 22 out of the 30 patients decided to forgo their previously prescribed medications once the study was over and continue using medicinal marijuana to manage their symptoms.

    Albeit with a very small sample group, this study provides some of the first clinical data on the potential of marijuana in treating ADHD, which, as we know, is characterized by difficulty concentrating, hyperactivity, impulsivity, and forgetfulness.

    Dr. David Bearman, a so-called figurehead of cannabis research, a.k.a. a “cannabinoidologist,” explains the effects of marijuana in treating ADHD symptoms as having to do with the brain’s dopamine levels.

    “Cannabis appears to treat ADD and ADHD by increasing the availability of dopamine,” Bearman explains (via Leafly). “This then has the same effect but is a different mechanism of action than stimulants like Ritalin and dexedrine amphetamine, which act by binding to the dopamine and interfering with the metabolic breakdown of dopamine.”

    Cannabis  (more specifically, the cannabinoids)  possibly corrects dopamine shortages in the brains of people with ADHD. As of now, two states in the United States—California and Colorado—allow the prescription of medical marijuana to treat ADHD, but if more studies prove out the results in this one, don’t be surprised if more states follow suit.

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    7 Tips to Juicing Fresh Cannabis in a Healthy Diet

    Cannabis is one of the most beautiful plants on Earth with few others  matching its versatile medicinal uses. Many scientific publications have shown the cannabinoids from juices and extracts are very effective against diseases such as cancer, epilepsy & seizures, asthma, migraines, MS, IBS, Alzheimer’s and many other diseases. Some believe that raw cannabis should be treated as a dietary staple.

    The body is able to tolerate larger dosages of cannabinoids when cannabis is consumed in the raw form. This is because when you smoke cannabis, the THC actually acts as a CB1 receptor agonist and your body can only absorb about 10 mg at a time

    CBD works on receptors, and as it turns out, we have cannabinoids in our bodies, endogenous cannabinoids, that turn out to be very effective at regulating immune functions, nerve functions, and bone functions. The endogenous cannabinoid system acts as a modulator in fine-tuning a lot of these systems, and if something is deranged
    biochemically in a person’s body, it may well be that a cannabinoid system can bring things back into balance.

    Now we know all this is very exciting, but do not go throwing your dispensary buds in the juicer thinking your about to make a magic healing potion. Here are 7 tips on juicing raw cannabis:

  • When it comes to juicing, as with any vegetable, the fresher the better.
  • Cannabis that has been dried and prepared for smoking is NOT suitable for juicing.
  • Juice 15 leaves, and 2 large (2 to 4 inches long) raw buds per day.
  • Raw buds are flowers harvested when the THC glands are clear rather than amber.
  • It is recommended that you mix in another vegetable juice to cut the bitterness of the raw cannabis.
  • A popular choice is carrot juice – a ratio of 1 part cannabis juice to 10 parts carrot juice.
  • Split the drink into 3 parts and drink with each meal, or store for up to 3 days in a tightly sealed container

    • When juicing raw plant material, no psychoactive THC is consumed because the molecule simply is not present in the plant. Thus, patients who juice experience no euphoria.

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    Exercise and Marijuana May Have Similar Effect On Pain

    Leaf Science – Exercise and Marijuana May Have Similar Effect On Pain

    Scientists have brought new meaning to the term ‘runner’s high.’ Findings suggest that exercise can activate the same pain-relieving pathways as marijuana.

    The euphoria and pain suppression that occur during high-intensity exercise were once believed to be the result of natural opioids called endorphins. But since the discovery of the endocannabinoid system in the mid-90s, evidence has pointed to natural marijuana-like molecules as the true explanation.

    Published in the journal Neuropharmacology, new findings from Brazil confirm the role of the endocannabinoid system in exercise-induced pain relief.

    “These results indicate that exercise could activate the endocannabinoid system, producing antinociception.”

    In the study, rats that underwent high-intensity exercise showed greater tolerance for pain – caused by changes in CB1 receptors of the brain.

    Get Your Copy Today

    CB1 receptors are activated by compounds in marijuana as well as naturally-occurring cannabinoids such as anandamide. In either case, activity of CB1 receptors has been shown to interfere with pain signaling at both the brain and spinal cord level.

    Interestingly, in areas of the rat brain involved with pain regulation, exercise appeared to increase both the activity and availability of these receptors. Blood levels of anandamide were also higher after exercise.

    The results, the authors suggest, could be useful for treating pain in certain groups of patients.

    “

    Our results demonstrated that moderate intensity exercise is effective at inducing antinociception, which can be of great importance for the treatment of several clinical pain conditions.”

    Pain relief from exercise has been documented since the 1980s, but has yet to be properly explained, they add.

    While more research needs to be done, previous studies involving human subjects have also shown higher endocannabinoid levels following exercise, suggesting that the same system might be at play in humans.

    Launch or Expand Your Cannabis Business with the Industry’s Top Experts.

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    The Ironic Comparison Of Cannabis and Pharmaceuticals

    The Ironic Comparison Of Cannabis and Pharmaceuticals

    Story Shared from CASHINBIS

    Comparing Testing, Health Benefits and Side Effects

    Proponents and advocates of the medical cannabis industry have long pointed at the pharmaceutical industry as to why medical cannabis is not further along in research, development and most importantly, application. On one hand, it would be a safe assumption to say that cannabis is currently one of the most tested and researched substances in America. However, the application of medical cannabis continues to move at a snail’s pace, if not a dead snail’s pace. On the other hand, America continues to see new pharmaceuticals pushed behind the counter of your local pharmacy nearly as quickly as they restock the candy aisle. So what is behind all of these pharmaceuticals, and their FDA approvals, that are being deemed as useful and effective in the treatments to which they are claiming? Well, it turns out that answer is much less than you think.

    In a recent analysis of the past 206 FDA supported pharmaceutical drugs, over 36% of those (74 drugs) were approved on the basis of a single clinical trial. Furthermore, many of those 200+ FDA approved drugs were passed through with little, if any, research as to the long-term side effects. Now, the theory behind the US Food and Drug Administration (FDA), as well as the public expectation, is that the FDA will test and vet these substances before they hit the market.

    Many Americans consider FDA approval as a legitimate medical claim. In fact, in a nationwide study of nearly 3,000 Americans, 39% reported that they believe the FDA only approves ‘extremely effective’ drugs. 25% of people in the same study are of the opinion that the FDA only passes pharmaceuticals that have no serious side effects. Unfortunately, this belief is very dangerous, for patients as well as medical physicians who might take the FDA endorsement at face value.

    In a recent analysis of the past 206 FDA supported pharmaceutical drugs, over 36% of those (74 drugs) were approved on the basis of a single clinical trial.1

    The blind leap of faith is not only dangerous due to the lack of clinical trials, but the side effects listed with these pharmaceuticals are vast and often overwhelming. A recent study conducted by Dr. Jon Duke, assistant professor of medicine at the Indiana University School of Medicine, analyzed 5,600 drug labels and found more than 500,000 listed effects. Their findings indicated that more commonly recommended pharmaceuticals came with an average of 100 side effects, with some listing as many as 525. Now, obviously most of the side effects listed are less than likely, but the fact that the FDA is passing these medicines, often with one clinical trial and an average of 100 side effects, says all that needs to be sad about the hypocritical state of the medical system in America.

    To make the comparison, feel free to visit PubMed, the National Library of Medicine’s database. A simple search for the term ‘cannabis’ will yield you over 14,000 studies, dating all the way back to 1843 and Dr. John Clendinning’s ‘Observations on the Medicinal Properties of the Cannabis Sativa of India.’ Now, a study is certainly not a clinical trial. However, as cannabis is federally illegal, those clinical trials have not been allowed and are left as ‘studies’. If we could speculate that those studies would have turned in to legal clinical trials, which, given the ‘anecdotal’ medicinal evidence, would be the case, then we could assume a certain percentage of these 14,000 studies would have become legal trials.

    If we were then so bold as to take the FDA single-study approval percentage and apply it to even a third of these studies, you would have well over 1,000 cannabis related medications approved for medical use. However, currently the FDA has approved 0 cannabis related substances for medicinal use.

    The National Cancer Institute, the federally recognized authority on cancer research, recently released their findings that ‘Cannabis has been shown to kill cancer cells in the laboratory.’

    But what about the long-term side effects? Cannabis has to be as bad for you as the pharmaceutical alternative, right? Well that depends on who you ask. If you were to ask Dr. Jordan Bechtold, a psychology research fellow at the University of Pittsburg, he would say that cannabis use, especially as a teenager, does not lead to long-term side effects. Dr. Bechtold was part of a recent research group who, in conjunction with PITT and Rutgers University, followed 408 males from adolescence to their mid 30’s for the study. The findings were thereafter published in Psychology of Addictive Behaviors and disseminated through the American Psychological Association (APA).

    “What we found was a little surprising. There were no differences in any of the mental or physical health outcomes that we measured regardless of the amount of frequency of marijuana used during adolescence.” – Dr. Jordan Bechtold – University of Pittsburg Psychology Research Fellow

    In the spirit of comparison, a simple search for ‘pharmaceutical long-term effects’ yields dozens of results that correlate to studies showing drastically negative side effects to long-term prescription pharmaceutical consumption. Not to mention the reported prescription drug overdose total, which according to the National Institute on Drug Abuse, a federally operated agency, in 2013 topped 24,000 people, 15,000 more than heroin.

    So, in order to potentially overdose on a cannabis edible, one would have to eat 2.2 million times the suggested dose in 15 minutes.

    Now, in order to hit the comparison out of the park, one most point out one last bit of information. Throughout the history of cannabis consumption, as far as we can trace it back that is, there are no documented cases of a cannabis consumer dying from overdose. It’s been reported that science has, however, figured out the amount of cannabis one would need to consume edibly in order to be at risk for a lethal reaction. That number is 22 kilograms. The recommended dose for a cannabis edible is 10 millagrams. So, in order to potentially overdose on a cannabis edible, one would have to eat 2.2 million times the suggested dose in 15 minutes. In terms of smoking cannabis, those numbers are comically more impossible to reach.

    The point of all of this information is not to demonize the pharmaceutical industry, and not to glorify cannabis as the end-all perfect solution to medical treatments. Rather, this article simply aims to jumpstart the conversation as to the hypocrisy in which America allows medical treatments to be developed and approved for human consumption. For those who already knew this information, it is a data and research based compilation they can share with the skeptics in their lives. These studies are not coming from the cannabis community. Instead, these studies are coming from national renown medical colleges and federally funded research. In fact, the National Cancer Institute, the federally recognized authority on cancer research, recently released their findings that ‘Cannabis has been shown to kill cancer cells in the laboratory.’

    So we did it. We’ve found a possible cure for cancer. After all of these years, and the billions of dollars that have gone towards researching this terrible disease, America has finally found something that could reverse the curse and treat suffering and dying patients. Let’s throw it in a single clinical trial and push it through the FDA. Oh wait…the treatment is cannabis related? Whoops. Never mind, back to the drawing board. This is the state of medicine in America right now. Sadly, this is not just one man’s opinion. This information is based on facts, research and information that is accessible to everyone, even the American government. Your move America.

    What are your thoughts on this comparison? What do you think needs to happen so that cannabis can be treated in the same medical light as the pharmaceutical world? Do you even want it to be?

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    A Beginner’s Guide to Consuming Medical Cannabis

    There are practical limits unique to each person for consuming medical Cannabis. Each consumption method requires a different dosage for your unique condition. Please keep in mind that Medical Cannabis is “Medical-Grade” meaning, it’s not for everyone. If you’re going to use the self-titrating method, remember, starting with a small amount and gradually increasing the dose is […]

    Cannabis-Treatable Epilepsy Research

    Medical Marijuana Research

    The State Department of Health have “seizures, including those characteristic of epilepsy, or severe and persistent muscle spasms, including those characteristic of multiple sclerosis or Crohn’s disease” on their list of “debilitating medical conditions” for which a licensed physician may certify a patient for the Hawaii State Medical Use of Marijuana Program. Parents seeking treatment for […]

    Desperate Journey Trailer and Full Video

    Colorado has become a promised land for desperate parents trying to save their children. In the past year-and-a-half, hundreds of families from across the country have uprooted their lives and moved here for a special kind of medical marijuana. They arrive with children suffering from incurable forms of epilepsy, life-threatening disorders with seizures that not […]

    CME-certified Curriculum in Clinical Cannabinoid Medicine

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    Developed by the Society of Cannabis Clinicians (SCC), this is the first comprehensive, online CME-certified Cannabis curriculum in Clinical Cannabinoid Medicine designed to educate the practicing clinician on both the research and clinical practice aspects of the therapeutic use of cannabis. Each course within the curriculum offers up to 1 AMA PRA Category 1 Credit […]

    Sharon Kelly: Cannabis Killed My Terminal Stage 4 Lung Cancer

    “The ED Doctor came out and motioned for us to come into her office & sit down not saying a word. She opened the conversation with I’m so very sorry…..what?? I’m so very sorry. There appears to be a sizable mass in your left lung – what? What is it? Have you ever smoked? What? […]

    Research Articles on Cannabis-treatable Diseases

    Research articles on Cannabis treatable diseases are being organized less by traditional government agencies and more by independent researchers. Cannabis research compiled and published by Government, University and private laboratories conducting research in states where Cannabis is legal. Compiling the research is a key important step towards providing Doctors with the information they need to make accurate and […]

    Cannabis Natural Antibiotic Properties

    Those of us in the Hawaii Cannabis Organization have longed believed that Cannabis will emerge not only as a treatment for symptoms of disease and effective antibiotic but also as preventative medicine. The Federal government reached similar conclusions before they patented THC in 1999. Read U.S. Cannabis patent. The abstract provides valuable insights into the US […]

    Sophia’s Story

    “We’ve tried everything else that they could possibly come up with to try and stop these seizures,” says Scott Nazzarine, Sophia’s father, “None of it has worked. We need legislation that allows our child to get the medicine she needs. But with or without it, we will continue to give our child what she needs […]

    Dosing Guidelines from Mayo Clinic

    Medical Marijuana Research

    Cannabis has unique interactions with each individual including various side-effects. So please use and dosing recommendations you find a guide only. Until Cannabis research is allowed at the Federal level, self-titration is the best method for determining the correct dosage for your cannabis-treatable disease or other debilitating health condition. — from Mayo Clinic: Marijuana (Cannabis […]

    Federal Minimum – Maximum Sentencing Guidelines for Marijuana

    In fiscal year 2013, there were 4,768 marijuana trafficking offenders, who accounted for 21.5% of all offenders sentenced under the drug trafficking guidelines. The number of marijuana offenders decreased by 29.8% from the 6,792 offenders in fiscal year 20123 . Get more details and quick facts about Federal Minimum – Maximum Sentencing Guidelines for Marijuana from […]

    Cannabis Safety

    Cannabis safety starts with you. Properly label and store in a safe place away from pets and children! Ingesting cannabis: Ingesting cannabis has many benefits over smoking it, the most important of which is the bypass of dangerous chemicals entering the respiratory system. Carcinogens and tars are largely left behind in the preparation for eating […]

    Cannabinoids Potential Anti-cancer Agents Research

    Medical Marijuana Research

    CANNABINOIDS: POTENTIAL ANTI-CANCER AGENTS Manuel Guzmán Cannabinoids — the active components of Cannabis sativa and their derivatives — exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating […]

    Medical Marijuana Liquid Extracts for Children with Severe Epilepsy

    WASHINGTON, DC – A medicinal liquid form of marijuana may show promise as a treatment for children with severe epilepsy that is not responding to other treatments, according to a study released today that will be presented at the American Academy of Neurology’s 67th Annual Meeting in Washington, DC, April 18 to 25, 2015. “The […]

    New Video Tells Powerful Story of Young Epilepsy Patient without Safe Access to Medical Marijuana

    The Drug Policy Alliance and Learn Liberty have teamed up to tell the emotional story of Sophia Nazzarine, a 7-year-old girl suffering from uncontrolled epilepsy, in a new video.

    Between clips of Sophia singing and playing with her parents in her hometown of Cincinnati, the audience is shown saddening footage of Sophia seizing as a newborn, while her parents describe their discovery of Sophia’s epilepsy and their exhaustive struggle to find an effective treatment.

    Click here to watch moving video of Sophia’s Story

    “We’ve tried everything else that they could possibly come up with to try and stop these seizures,” says Scott Nazzarine, Sophia’s father, “None of it has worked. We need legislation that allows our child to get the medicine she needs. But with or without it, we will continue to give our child what she needs to reduce her dangerous seizures.”

    Sophia’s story is complemented by interviews with doctors, explaining her condition and the strong potential for its treatment with marijuana.

    “The belief is that it’s the cannabadiol portion of [the marijuana plant] that seems to have less intoxicating effects and more of the anti-seizure effects,” explains Dr. Michael D. Privitera, Professor of Neurology at the University of Cincinnati.

    “There are millions of people, young and old, just like Sophia, suffering from serious illnesses for which their doctors are out of ideas,” said DPA’s Dr. Amanda Reiman in response to the video, “They are out of options in the realm of traditional medical care and they deserve to have every option on the menu, and in 23 states plus Washington DC, they do.”

    The video is being released just as legislation has been introduced by Senators Cory Booker (D-NJ), Rand Paul (R-KY), and Kirsten Gillibrand (D-NY) to allow those state programs to exist. The Compassionate Access, Research Expansion and Respect States – CARERS – Act is the first-ever bill in the U.S. Senate to legalize marijuana for medical use and the most comprehensive medical marijuana bill ever introduced in Congress.

    The video ends by asking viewers to help create legal access to medical marijuana by supporting the Drug Policy Alliance as Sophia reads with her mother.

    “Spending a week with Sophia and her family while filming this documentary was a life-changing experience. Sophia is truly an amazing girl whose story is helping to educate millions of people about why she can’t get the simple medication she needs,” said Tim Hedberg, the producer of the video for Learn Liberty.

    The Drug Policy Alliance is the nation’s leading organization promoting alternatives to the war on drugs.

    Learn Liberty is your resource for exploring the ideas of a free society. They tackle big questions about what makes a society free or prosperous and how we can improve the world we live in. Learn Liberty is a project of the Institute for Humane Studies at George Mason University.

    Scott and Nicole Nazzarine have both made themselves available to any media outlets with further interest in their daughter’s story. Unreleased photos and footage are also available to these outlets for free use.

    Author:
    Date Published: April 22, 2015
    Published by Drug Policy Alliance

    Comparative Risk Assessment Illicit Drugs

    Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach. Abstract A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose […]

    American Academy of Pediatrics Wants Feds to Loosen Research Restrictions on Marijuana

    In a new paper, AAP (American Academy of Pediatrics), which focuses on the well-being of children and young adults, said it opposes legalizing medical marijuana outside the traditional US Food and Drug Administration regulatory process, as several states have done. But the organization acknowledged that further research could provide insight into the medical use of […]

    ‘Marijuana Can Be Helpful,’ Admits Surgeon General on CBS News

    [su_video url=”http://www.cbsnews.com/videos/new-surgeon-general-dr-vivek-murthy-measles-vaccine-is-safe-and-effective/” poster=”https://hawaiicannabis.org/wp-content/uploads/hawaii-medical-marijuana-beliefs.jpg.pagespeed.ce.4w9uw1YR1L.jpg”] Time to reschedule. Did you know marijuana is classified federally as a schedule 1 drug. This comes with minimum mandatory sentencing that currently puts medical marijuana patients in prison with heroin traffickers, rapists murderers etc. Drugs / Substances listed in DEA Schedule I include: Heroin (diacetylmorphine) LSD (Lysergic acid diethylamide) Marijuana (cannabis, […]

    Monitoring Health Concerns Related to Marijuana in Colorado: 2014

    Changes in Marijuana Use Patterns, Systematic Literature Review, and Possible Marijuana-Related Health Effects Medical marijuana has been legal in Colorado since 2000, and medical use was primarily viewed as an individual doctor/patient decision outside the scope of public health policy. Commercialization of medical marijuana in 2009 prompted a large increase in the number of individuals with active medical […]

    Documentary | Marijuana Nation

    Published on Dec 27, 2012 The National Geographic Channel, covers the ongoing global battle over marijuana prohibition, its history, and the growing culture of cannabis use for recreational and medical purposes. Reporter Lisa Ling visits Vancouver’s Pot Block, as well as some secret and not-so-secret marijuana growing operations and other relevant pot spots. Marc Emery, […]

    Documentary | Medical Cannabis and Its Impact on Human Health a Cannabis

    Published on Oct 21, 2013 Doctors: Dr. Donald Tashkin Dr. Donald Abrams Dr. David Bearman Dr. Robert Sterner In this myth shattering, information packed documentary, learn from physicians and leading researchers about medicinal cannabis and its demonstrated affects on human health. Topics include: *What the consensus is from over 15000 scientific and medical trials *What […]

    Taima Hakubutsukan and Japanese Cannabis Tradition

    “Most Japanese people see cannabis as a subculture of Japan but they’re wrong. For thousands of years cannabis has been at the very heart of Japanese culture,” explains Takayasu Junichi, one of the country’s leading experts. “However after Japan’s surrender in 1945, U.S. authorities occupied the country and they introduced American attitudes towards cannabis. Having […]

    Science of Cannabis (for Doctors)

    Project CBD | CANNABIDIOL SCIENCE | FOR DOCTORS | FOR PATIENTS by Americans for Safe Access Published on Feb 6, 2013 Many physicians refrain from approving Cannabis use by patients because they learned nothing about Cannabis in medical school and cannot knowledgeably advise patients about dosage, side effects, mechanism of action, etc. This talk by […]

    The Endocannabinoid System: How cannabis oil works

    Published on Jul 24, 2012 Since 1974 studies have shown that cannabis has anti-tumor effects. The results of the 1974 study, reported in an Aug. 18, 1974, Washington Post newspaper feature, were that cannabis’s component, THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives […]

    Documentary – Bud Buddies: Project Storm (trailer)

    Bud Buddies: Project Storm (trailer) Published on Mar 12, 2014 In June 2002, tucked away in the depths of the University of Madrid’s biochemistry building an inconspicuous event took place that would shape the future of cancer treatment over the coming decades. It wasn’t planned; in fact it was down to the pure chance that […]

    ADHD Not a Real Disease

    One of the world’s leading pediatric neuroscientists, Dr. Bruce D. Perry, M.D., Ph.D, recently stated publicly that Attention Deficit/Hyper-Activity Disorder (ADHD) is not ‘a real disease,’ and warned of the dangers of giving psycho-stimulant medications to children. ADHD Not a Real Disease according to Dr. Perry. Dr. Perry noted that the use of medications like […]

    Eating Enough Phytocannabinoids Can Cure Almost Every Disease

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    Prescription Drug Warning – zohydro

    Zohydro FDA Approved

    We know many of the new “legal” drugs we see advertised on television include some pretty major side-effects. Anal Bleeding for example is apparently acceptable. Prescription drugs are now the number one killer in preventable deaths according to Sanjay Gupta (see video below from CNN). “In the midst of a severe drug epidemic fueled by […]

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