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You may find these notes helpful in your journey or sharing with a loved one who may be interested. This is not medical advice. You must consult a medication professional prior to considering the rest of the information. Your loved one may already be on a medication regimen that might include something like 15mg extended-release morphine tabs every 6 hours, Percocet PRN, and gabapentin every 6 hours. Your loved one may also be interested in exploring the potential benefits and risks of combining Black Seed Oil and Full-Spectrum Cannabis Oil (RSO) with their existing medication regimen. You may find the Rick Simpson Protocol helpful.

Medical Notes: Combining Black Seed Oil and Full-Spectrum Cannabis Oil (RSO) with Existing Medication Regimen

Black Seed Oil Benefits

  • Anti-Inflammatory: Black Seed Oil has been shown to have anti-inflammatory properties. Source
  • Antioxidant: It has potent antioxidant effects. Source
  • Neuroprotective: Studies have indicated its potential in neuroprotection. Source
  • Anti-Cancer: Some studies suggest it may have anti-cancer properties. Source

Full-Spectrum Cannabis Oil (RSO) Benefits

  • Pain Management: Known for its potent analgesic effects. Source
  • Anti-Inflammatory: Has anti-inflammatory properties. Source
  • Antioxidant: Contains antioxidants like CBD and THC. Source
  • Neuroprotective: Some cannabinoids have shown neuroprotective effects. Source

Potential Concerns

Drug Interactions

Both Black Seed Oil and RSO have potential interactions with other medications, particularly those metabolized by the liver.

Synergistic Effects

Combining multiple substances that have similar effects can lead to enhanced effects, which might be either beneficial or harmful.

Liver Load

The liver metabolizes many medications, and adding more substances could potentially strain the liver.

CNS Depression

Both Percocet and gabapentin can cause CNS depression, which might be exacerbated when combined with other substances that have similar effects.

Tolerance and Dependence

Combining multiple substances can sometimes lead to increased tolerance or dependence.


  1. Consult a Healthcare Provider: Given the complexity and potential for interactions, it’s crucial to consult a healthcare provider for personalized advice.
  2. Pharmacokinetic Testing: Some healthcare providers might recommend pharmacokinetic testing.
  3. Regular Monitoring: Frequent check-ups and lab tests may be necessary.
  4. Step-by-Step Introduction: If approved by your healthcare provider, introduce one new element at a time.
  5. Adjustment of Existing Medications: Your healthcare provider may need to adjust the doses of your existing medications.


Given the complexity of the medication regimen and the potential for interactions and side effects, it’s crucial to consult a healthcare provider for personalized advice. Please consult a healthcare provider for the most accurate and personalized advice.

Thymoquinone, Thymohydroquinone, and Thymol:

Property/Compound Thymoquinone Thymohydroquinone Thymol
Source Nigella sativa (Black Seed) Nigella sativa (Black Seed) Thyme oil, smaller amounts in Nigella sativa
Anti-Inflammatory Inhibits pro-inflammatory cytokines like TNF-α and IL-6 Not well-studied Used in traditional medicines for respiratory conditions
Antioxidant Scavenges free radicals, enhances antioxidant enzymes Possesses antioxidant properties, mechanisms not well understood Less potent than thymoquinone
Anti-Cancer Induces apoptosis, inhibits angiogenesis in various cancer types Not well-studied Not well-studied
Neuroprotective Protects against neurodegenerative diseases like Alzheimer's and Parkinson's Potential candidate for treating Alzheimer's due to anti-cholinesterase activity Not well-studied
Anti-Microbial Demonstrates anti-microbial activity Demonstrates anti-microbial activity against various pathogens Strong anti-microbial properties, used in dental products
Pharmacokinetics Low oral bioavailability, research on nanoformulations ongoing Bioavailability and safety profile need further investigation Generally recognized as safe (GRAS) by the FDA
Safety Generally safe at therapeutic doses, high doses may be toxic Not well-studied Safe in food, can be skin-irritating in high concentrations
Other Uses Undergoing clinical trials for various applications Less studied, needs more research Used as a flavoring agent, preservative, pesticide, and fumigant
Interactions with Cannabis Compounds Not well-studied, potential for synergistic anti-inflammatory effects Not well-studied, potential for synergistic anti-inflammatory effects May interact with cannabinoids to enhance anti-microbial and anti-inflammatory effects