Verified June 2016 by University of Electronic Science and Technology of China
Sponsor:
Collaborators:
German Research Foundation
University Hospital, Bonn
Information provided by (Responsible Party):
Benjamin Becker, University of Electronic Science and Technology of China
ClinicalTrials.gov Identifier:
NCT02801422
First received: June 11, 2016
Last updated: June 11, 2016
Last verified: June 2016
The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.
| Cannabis Dependence | Other: fMRI |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Altered Neural Activation Patterns of Emotional Processing in Dependent Cannabis Users Associated With Relapse |
- fMRI neural activation patterns of emotional processing [ Time Frame: one time point = fMRI assessment after minimum 24 hours of abstinence ] [ Designated as safety issue: No ]
Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects
| Estimated Enrollment: | 75 |
| Study Start Date: | February 2016 |
| Estimated Study Completion Date: | February 2018 |
| Estimated Primary Completion Date: | March 2017 (Final data collection date for primary outcome measure) |
| Cannabis Dependence
ages 18-40 |
Other: fMRI |
| Healthy control subjects
socio-demographically matched |
Other: fMRI |
| Ages Eligible for Study: | 18 Years to 40 Years (Adult) |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Cannabis dependent individuals
Inclusion Criteria:
- Cannabis Dependence
- 24 hours abstinence
Exclusion Criteria:
- other DSM-4 diagnosis
- neurological disorder
Please refer to this study by its ClinicalTrials.gov identifier: NCT02801422
| University of Bonn | |
| Bonn, North Rhine Westfalia, Germany, 53127 | |
| Contact: Benjamin Becker, PhD +4917620090499 ben_becker@nullgmx.de | |
| Contact: Kaeli Zimmermann, MSc +4922828719704 kaeli.zimmermann@nullgmx.de | |
University of Electronic Science and Technology of China
German Research Foundation
University Hospital, Bonn
| Responsible Party: | Benjamin Becker, Prof. Dr. rer. nat. Benjamin Becker, University of Electronic Science and Technology of China |
| ClinicalTrials.gov Identifier: | NCT02801422 History of Changes |
| Other Study ID Numbers: | ART_Can_03 |
| Study First Received: | June 11, 2016 |
| Last Updated: | June 11, 2016 |
| Health Authority: | Germany: Ethics Board University Bonn |
Keywords provided by University of Electronic Science and Technology of China:
| cannabis fMRI addiction relapse |
Additional relevant MeSH terms:
| Recurrence Marijuana Abuse Disease Attributes Pathologic Processes |
Substance-Related Disorders Chemically-Induced Disorders Mental Disorders |
ClinicalTrials.gov processed this record on August 25, 2016