This week’s New Strains Alert delivers a collection of up-and-coming classics from Ocean Grown Seeds and dishes up a few white-hot user-submitted strains for the weekend. Sequoia Strawberry is a fantastic fruity cross of White Strawberry and White Nightmare that will put a sizzle in your brain and some pep in your step. If you […]
This week’s New Strains Alert is stacked high with fruity genetics. Grape Calyx by Calyx Garden is a nuanced complex of strains that has been in development since 2012 and offers deep Kush and Cookies elements for the refined cannabis connoisseur. Ninja Fruit from our pals at Ocean Grown Seeds reeks of a phenomenal Haze […]
This week’s New Strains Alert is stacked high with fruity genetics. Grape Calyx by Calyx Garden is a nuanced complex of strains that has been in development since 2012 and offers deep Kush and Cookies elements for the refined cannabis connoisseur. Ninja Fruit from our pals at Ocean Grown Seeds reeks of a phenomenal Haze […]
Stakeholders to develop, improve legislation; first meeting slated Wednesday in Honolulu The group tasked with developing and recommending legislation to improve the medical marijuana system to ensure safe and legal access to qualifying patients is scheduled to have its first meeting in Honolulu on Wednesday. The Act 230 Medical Marijuana Legislative Oversight Working Group will […]
This week’s New Strains Alert includes some local favorites alongside a few up and coming heavy hitters. We’ve added some outstanding OG crosses, including Lemonder (Lavender x OG Kush) and Chem D.O.G. (Chemdawg x OG Kush). With complex terpene profiles and the right balance of heavy and heady, these OG’s are ready for the weekend. […]
This week’s New Strains Alert has some fruity and floral favorites for the discerning cannabis consumer. Lemon Larry (AKA Larry OG) is a phenomenal citrus-loaded Kush cut that gains potency and dimension through the addition of the Linalool-rich genetics of Lavender. If berries are more your style, dig into the sweet, resinous foliage of Appalachian […]
During the pregnancy of her 5th child, a young Washington mother named Jessamyn Way developed terrible migraine headaches, fainting spells, and blood pressure problems. After the birth of her child, she was sent to a Hospital ER where a CAT scan revealed that she had a brain tumor deep within her skull. She was told […]
Mahalo for Being You. We couldn’t fit all the gratitude on one page so we create a special mahalo page. Please check it out and give thanks for all the attendees, patients, caregivers, sponsors, presenters, volunteers, vendors, artists and other local businesses who made this event successful. Visit the Hawaii Cannabis Gratitude page. Educational Conference Classes […]
Radiation treatment for Kelly Oliphant’s Stage 4 prostate cancer left him with radiation colitis and cystitis. “I have, from one hip to the other in the front, a six-inch belt that burns constantly,” Oliphant explains. “It’s like having a sunburn on the inside of your skin. One doctor related it to having shingles.” Oliphant endured […]
A pair of bills to establish guidelines for Guam’s stalled medical marijuana program are likely to go before lawmakers for debate during their October session. Voters approved the Joaquin KC Concepcion II Compassionate Cannabis Use Act in the 2014 General Election, and the Department of Public Health and Social Services drafted the rules and regulations […]
Dayton, Ohio – Medical marijuana is now the law in Ohio but parents with sick children, especially those suffering from debilitating seizures, said they were frustrated because it may still take up to two years before they have access to the drug. Lindsay Sandlin was just 9-years-old when her parents started pushing for the passage […]
Proper joint rolling is considered a fine art in many social circles. There’s something special about a properly rolled, evenly burning joint that seems to last as long as you want it to. Unfortunately, not all of us have the magic green touch and joint rolling can be somewhat of a cumbersome task. One opportunity […]
This article is sponsored by Firefly, a San Francisco-based technology company that specializes in the research, design, and manufacturing of vaporizer hardware. Cannabis concentrates aren’t going anywhere. This segment of the market – which includes waxes, shatters, hash oils, rosins, tinctures, and more – is expanding at lightning speed, and may give us the most compelling vision […]
The NSW government will begin a medicinal-cannabis trial at the Calvary Mater Newcastle hospital for patients with advanced cancer “in the coming months”. “Researchers are finalising the necessary arrangements to enrol the first patients soon,” a spokeswoman for the government’s Centre for Medicinal Cannabis Research and Innovation said. “The researchers are importing a leaf product, […]
Is marijuana a gateway drug? Carrie Roberts sure hopes so. Roberts, a consultant with Colorado-based Medicine Man Technologies, doesn’t believe that marijuana use leads to abuse of harder drugs, though. Instead, she thinks it might present a gateway out of risky drug use for people struggling with opioid dependency. “I think we could save a […]
As many Americans approach November 4 with a sense of dread, facing the fact that either Donald Trump or Hillary Clinton will be the next president, much more hopeful things will be going on that day. Residents in at least nine states will be voting on ballot initiatives to legalize recreational or medical cannabis use. […]
A stunning video has been made by a man living with Parkinson’s Disease to demonstrate the relief he gets from using cannabis to self-treat his symptoms. Ian Frizell has posted a short film to show why he supports the drug’s legalisation, calling for MPs to back its legal use for treating medical conditions. He said, […]
This week’s New Strains Alert is a full house of hybrid buds that reach toward indica or sativa dominance but don’t quite hit the mark. That’s not to say the effects of these strains are weak or without nuance, but rather an illustration of the middle ground they inhabit with their complementary mental and physical […]
At 10 months of age, Kalel Santiago of Puerto Rico was diagnosed with a rare form of cancer called neuroblastoma. He endured chemotherapy, radiation treatments, and surgery for two years – and survived. Then he was diagnosed with something permanent: severe autism that disabled him from speaking. “While he was in the hospital, we noticed […]
Kansas City, Mo. – A Kansas City mom wants Missouri voters to legalize medical marijuana for patients who need it, like her son with severe epilepsy, but politicians are blocking it from going on November’s ballot. “I’m very upset because these elected politicians are trying to stop something that we the people who put them […]
Dingmans Ferry When Brenden Doran of Dingmans Ferry was only three weeks old, he got very sick. When he threw up, the contents of his stomach flew five feet from his bassinet. He was losing weight. Doctors prescribed medicine but it didn’t work. It took weeks before they identified the problem: pyloric stenosis, the narrowing […]
Corinne Malanca credits CBD oil with saving her father’s life. Five years ago, Stan Rutner underwent chemotherapy for Stage 4 lung cancer. After treatment, an inoperable brain tumor was found and he fell sick with pneumonia caused by his radiation treatments. Thinking Rutner only had weeks to live, Malanca turned to the internet for answers. […]
Medical cannabis is slowly becoming part of the mainstream discussion in the UK. The NHS is trialling a cannabis vape pen, you can now buy medical oils with a high CBD content (the chemical in weed that helps mitigate the symptoms of lots of nasty ailments) and just last week a parliamentary report recommended that […]
PRESS RELEASESAN LUIS OBISPO, CA, September 14, 2016 – Cannabis testing labs across the United States are signing up for the Fall 2016 Emerald Test Inter-labComparison and Proficiency Test (ILC/PT), in an effort to advance quality assurance in the industry. Labs interested in joining the contest have until September 21 to registerthrough the Emerald Test […]
HONOLULU (HawaiiNewsNow) – The state’s Medical Marijuana Registry office only has a handful of workers, and they’re responsible for keeping up with the growing demand for medical marijuana cards. The small staff processes and verifies approximately 1,200 applications a month. Once patients get a card, they’re allowed to legally obtain medical marijuana. “Every single app that […]
Dutch cannabis sales are moving into the 21st century despite the industry’s legal status being stuck in a bygone era. Before long, buds of dubious provenance may become relics of the past. Two Dutch coffeeshops have begun providing customers with extensive information about the cannabis they sell, including lab-verified cannabinoid content, strain information, batch numbers, […]
Karlee lives in a quiet town in southeastern Washington. Last year, she put in a new cedar fence around her home. The fence is 6 feet tall, and behind it Karlee grows tomatoes, zucchini, and marijuana. As it matures, the sweet smell of pot starts to waft into the neighborhood. This is Karlee’s cue that […]
This week’s New Strains Alert is a surprisingly sativa-dominant bouquet of flowers from Hawai’i, the circus, and a galaxy far, far away. We’ve added three distinct Hawaiian landrace strains that are loaded with tropical terpenes and history. For all the Chemdawg enthusiasts, dig into some Stardawg Guava, which combines two awesome Chemdawg cuts, Chemdawg 4 […]
MJ Freeway Program Manager, Tony Reese and Operations Consultant, Tyler Stratford share clear, actionable tips that you can implement immediately. They discuss compliance as a company culture, how to reduce risk, record keeping best practices, and more. Written by Jasmine on August 16, 2016
Cannabis can have an indefinite shelf life, but only if all of the proper conditions have been met. For cannabis to truly stand the sands of time, one must not only handle each process of the growth and harvest cycle carefully, but also store the cannabis properly. If all of these conditions are met, one could […]
It doesn’t take much to experience an enjoyable cannabis smoking session — some fine cannabis flower, a smoking apparatus with the appropriate heating mechanism, and perhaps a grinder are all that are really needed. Once everything is ready to go, however, there are a few variables that still may go awry, such as your cannabis […]
It’s a new week at Leafly and you know what that means…New Strains Alert, baby! This week we’ve added a Tangerine Haze cross called Tangenesia, Biochem for all the Chemdawg faithful, a couple entries from Tahoe Hydro, and more. Dig in and drop a comment if you’ve had the pleasure of any of these fine […]
There are many different ways to ensure you are maximizing your yield while also staying sustainable in your grow. While there are certainly various options out there , living soil is one we keep hearing about in the cannabis industry as being one of the best. This guide was concise and fairly simple to understand, […]
This week’s New Strains Alert is brought to you by you, the Leafly community! Thelonious Skunk, Sugar Pine, Apple Jack, Gorilla Biscuit, and others made this list via submissions to Leafly by growers, seed banks, and consumers, just like you. Here at Leafly we seek to share the communal knowledge of this wondrous flower and […]
The Coriolis acceleration assures hurricanes North the of the equator, spin counter-clockwise. Most hurricanes in Hawaii come from the South across Hawaii Nei. Wind is extremely variable during storms in Hawaii and is largely dependent on the geography of the area you live. Regardless, know where the prevailing winds will blow and place your plants […]
Hawai‘i’s Medical Marijuana Registry Program was signed into law in 2000, making Hawaii the first state to legalize medical-use cannabis via the legislature, as opposed to voter initiative. In 2015, Hawai‘i created the Medical Marijuana Dispensary Program, which gives permitted patients places to buy their cannabis. The program is administered by the state Department of Health, which will […]
Smoking the equivalent of a single ‘spliff’ of cannabis makes people less willing to work for money while ‘high’, finds a new UCL study. The research, published in Psychopharmacology, is the first to reliably demonstrate the short-term effects of cannabis on motivation in humans. The researchers also tested motivation in people who were addicted to […]
Steep Hill, the global industry leader in cannabis testing and analytics, today announced it has licensed its cannabis testing technology to Spectra Analytical Lab, which is run by a highly respected team known for cannabis science, patient advocacy and educational event production in Hawaiʻi. Once approved by the Hawaiʻi Department of Health, the team will […]
August 31, 2016– By Morgan Humphrey Today is International Overdose Awareness Day. Numerous families and friends will come together today to remember loved ones lost due to the failed war on drugs. Forty-plus years of ineffective policies have left millions without treatment and proven life-saving measures. The results are staggering: according to the CDC, in […]
August 31, 2016– By Stefanie Jones Whether or not you’re someone who uses alcohol or other drugs, undoubtedly you will be around people who do at some point. And being able to recognize when something’s gone wrong is the first step toward being able to take action – and possibly save a life. That’s why […]
A Toronto mother whose son suffers from chronic seizures due to a rare genetic condition is frustrated that some nurses in Toronto hospitals have refused to administer cannabis oil, which she says brings him relief. Maria Niembro, mother of 11-year-old Francesco, told CBC’s Metro Morning on Monday that she has to administer the cannabis oil […]
As more states and countries legalize medical and/or adult recreational marijuana use, the incidences of Prenatal Cannabis Exposure (PCE) will likely increase. While young people increasingly view marijuana as innocuous, marijuana preparations have been growing in potency in recent years, potentially creating global clinical, public health, and workforce concerns. Unlike fetal alcohol spectrum disorder, there […]
Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model.
Previous reports have demonstrated that the combination of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) botanical extracts, which are the components of an already approved cannabis-based medicine, reduce the Alzheimer-like phenotype of AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage. Here, we provide evidence that such natural cannabinoids are still effective in reducing memory […]
Endocannabinoids (eCBs) are endogenous mediators that along with the cannabinoid receptors (CB1 and CB2), a membrane transporter and metabolic enzymes form the endocannabinoid system (ECS). Several eCBs have been discovered with emphasis on anandamide (AEA). They are involved in several biological processes such as energy balance, immune response and reproduction. Decidualization occurs during the secretory […]
“I couldn’t help but notice your Pain…. It runs deep, share it with me.” -Tupac Shakur, “Pain” What is Pain? Seems to be a straight up question, but can you describe it? I’ve been thinking about this for quite some time now, and I am still hung up. How does one interpret their own pain, […]
Effects of continuation, frequency, and type of cannabis use on relapse in the first 2 years after onset of psychosis: an observational study.
BACKGROUND: Although cannabis use after a first episode of psychosis has been associated with relapse, little is known about the determinants of this most preventable risk factor for relapse of psychosis. Here we aimed to study whether the effects on outcome vary depending on the type of cannabis consumed and usage pattern. METHODS: In this […]
BACKGROUND: In ancient medicine, extracts of the marijuana plant Cannabis sativa were used against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of the Cannabis plant has remarkably advanced enabling us to use a variety of herbal and synthetic cannabinoid (CB) compounds to study the endocannabinoid system (ECS), a physiologic entity […]
BACKGROUND: Rapid reviews are of increasing importance within health technology assessment due to time and resource constraints. There are many rapid review methods available although there is little guidance as to the most suitable methods. We present three case studies employing differing methods to suit the evidence base for each review and outline some issues […]
I was diagnosed with Crohn’s Disease 12 years ago and got my first medical cannabis card in California around the same time. I have written about it online and I happily talk about it whenever prompted. I am frequently asked the same question, “what’s the best strain for Crohn’s Disease?” First and foremost, I am […]
The U.S. is in the grips of a well-documented opiate epidemic. More people in the country now die from heroin and prescription opiates than they do from car accidents. In 2014, nearly 19,000 fatal overdoses were related to legal opiates like Oxycontin and Vicodin, and according to the Center for Disease Control, at least half […]
Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age. Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing […]
A multidisciplinary team including researchers from the Montreal Neurological Institute has improved our understanding of how cannabinoids, the active agent in marijuana, affect vision in vertebrates. Scientists used a variety of methods to test how tadpoles react to visual stimuli when they’ve been exposed to increased levels of exogenous or endogenous cannabinoids. Exogenous cannabinoids are […]
Cannabis use has been associated with favorable outcomes on metabolic risk factors. The cause of this relation is still unknown. In this study we investigated whether this effect is mediated by the AKT1 gene, as activation of the related enzyme by cannabis may cause metabolic changes. Six Single Nucleotide Polymorphisms (SNPs) of the AKT1 gene […]
The economic crisis plaguing Greece was expected to impact consumption of pharmaceuticals and illicit drugs – a priori to an unknown extent. We quantified the change of use for various classes of licit and illicit drugs by monitoring Athens’ wastewater from 2010 to 2014. A high increase in the use of psychoactive drugs was detected […]
Worldwide, marijuana (cannabis) is a widely used drug. The incidence of marijuana smoking is increasing and is second only to tobacco as the most widely smoked substance in the general population. It is also the second most commonly used recreational drug after alcohol. Some adverse effects of marijuana smoking have been documented; however, the number […]
Although cannabis is widely used, it remains unclear which consumption patterns are more likely to produce future consequences (risky/hazardous use) or current damage (problematic/harmful use). This unresolved issue contributes to cannabis public health implications. In order to facilitate further consensus, this review analyzes previously used definitions in the literature. METHODS: This systematic review was performed […]
BACKGROUND: Acceptance of cannabis use is growing. However, prolonged use is associated with diminished psychosocial outcomes, potentially mediated by drug-induced cognitive impairments. Δ9-Tetrahydrocannabinol (THC) is the main psychoactive ingredient in cannabis, yet other phytocannabinoids in the plant, such as cannabidiol (CBD), have unique properties. Given that CBD can modulate the undesirable effects of THC, therapeutic […]
New research from the University of British Columbia suggests there may be some truth to the belief that marijuana use causes laziness — at least in rats. The study, published today in the Journal of Psychiatry and Neuroscience, found that tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana, makes rats less willing to try a […]
Brain imaging studies on the cognitive, pharmacological and neurobiological effects of cannabis in humans: Evidence from studies of adult users.
Cannabis is the most widely used illicit drug worldwide. Regular cannabis use has been associated with a range of acute and chronic mental health problems, such as anxiety, depression, psychotic symptoms and neurocognitive impairments and their neural mechanisms need to be examined. This review summarizes and critically evaluates brain-imaging studies of cannabis in recreational and […]
BACKGROUND: Cannabis is the most widely used illicit psychoactive substance world-wide, yet no medication is approved for the treatment of intoxication, withdrawal, or cannabis use disorder (CUD). OBJECTIVE: To comprehensively review the current state of knowledge. METHOD: Search of the PubMed electronic data base and review of reference lists of relevant articles to identify controlled […]
The problematic use of Information and Communication Technologies (ICT) in adolescents by the cross sectional JOITIC study.
BACKGROUND: The emerging field of Information and Communications Technology (ICT) has brought about new interaction styles. Its excessive use may lead to addictive behaviours. The objective is to determine the prevalence of the problematic use of ICT such as Internet, mobile phones and video games, among adolescents enrolled in mandatory Secondary Education (ESO in Spanish) […]
BACKGROUND: There are reports that the incidence of alcohol-involved crashes has remained stable among fatally injured drivers while drug involvement has increased in recent years. METHODS: Data from the Fatality Analysis Reporting System (FARS) from 2010 to 2013 were used to examine drug and alcohol status of drivers (N = 10 864) of 4-wheeled passenger vehicles […]
Cannabinoids and post-traumatic stress disorder: clinical and preclinical evidence for treatment and prevention.
There is substantial evidence from studies in humans and animal models for a role of the endocannabinoid system in the control of emotional states. Several studies have shown an association between exposure to trauma and substance use. Specifically, it has been shown that there is increased prevalence of cannabis use in post-traumatic stress disorder (PTSD) […]
The aim of this study was to analyze 26 various illicit drugs, psychopharmaceuticals and metabolites thereof in sewer from 17 selected wastewater treatment plants (WWTPs) in the Slovak and Czech Republics. Urinary bio-markers used were analyzed using liquid chromatography coupled with the tandem mass spectrometry (LC-MS/MS). We then compared our results with data obtained in […]
BACKGROUND AND PURPOSE: Essential tremor (ET) is a neurological disorder with unknown etiology. Its symptoms include cerebellar motor disturbances, cognitive and personality changes, hearing and olfactory deficits. Excitotoxic cerebellar climbing fibre hyperactivity may underlie essential tremor and has been emulated in rodents by systemic harmaline administration. Cannabinoid receptor agonists can cause motor disturbances although there […]
Harrisburg – Health Secretary Dr. Karen Murphy has provided an update on the implementation status of Pennsylvania’s medical marijuana program and announced the department is seeking input on its draft temporary regulations for growers and processors. “The Department of Health is being very thoughtful and thorough in developing this complex patient and medically-focused program,” said […]
The Marijuana Motives Measure (MMM), which is derived from a scale measuring alcohol use motives, has been the main instrument used to explore the role of motives in cannabis use and related problems. Two studies attempted to developed specific cannabis use motives but none of them showed a unique association to cannabis use and problems […]
Shalimar, Fla. – It’s called CBD Oil: short for Cannabidiol. And it was specially delivered this week to a little boy, JJ, short for Jonathan Junior. The parents of the nine year-old were presented with the first-ever delivery of cannabis oil in Northwest Florida. Their son was diagnosed with a rare form of epilepsy called […]
Countless activists, researchers and enthusiasts let out a collective whimper when the Drug Enforcement Administration upheld a 46-year-old policy of classifying marijuana as a Schedule I narcotic with no medicinal properties. But then, federal officials did something utterly unexpected and loosened restrictions on the cultivation of marijuana for research purposes. While that might sound counterintuitive, […]
BACKGROUND: Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case series of psychosis associated with acute recreational drug toxicity, and estimate the frequency of psychosis for different […]
Cannabinoid stability in oral fluid (OF) is important for assuring accurate results since OF has become a valid alternative matrix of choice for drug testing. We previously published OF cannabinoid stability studies using Quantisal™, Oral-Eze®, and StatSure™ devices stored at room temperature for 1 week, 4 °C for up to 4 weeks and in -20 °C up to 24 weeks. […]
BACKGROUND: The aim of this study was to investigate the relationship between psychotic-like experiences (PLEs) assessed using the Community Assessment of Psychic Experience (CAPE) questionnaire and the pattern of cannabis use in a non-clinical sample collected by snowball sampling. METHODS: Our sample was composed of 204 subjects, distributed into three groups by their cannabis use […]
The consumption of alcohol, tobacco, and other drugs has become a concern in high-performance athletes. Professional athletes are more exposed to drugs than the general population. Although some drugs are unquestionably detrimental to performance, several studies have nevertheless shown evidence of increased consumption of these substances within this sub-population. This review aimed to elucidate alcohol, […]
Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges.
RATIONALE: The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while responding prematurely before a light appears is […]
With an increase in the legalization of recreational marijuana across the USA, advertising for marijuana products is more widespread, especially on the Internet where such practices pose a regulatory challenge. In this study, we examined the content of marijuana advertising on Weedmaps, a popular website that markets marijuana retailers online. A total of 146 recreational […]
Premorbid cannabis use is associated with more symptoms and poorer functioning in schizophrenia spectrum disorder.
BACKGROUND: Cannabis use disorder is associated with an earlier age at onset and a more severe outcome of schizophrenia spectrum disorders. The role of cannabis use before the onset of illness (premorbid cannabis use) has not been fully investigated. We here examined how amount and type of premorbid cannabis use was associated with the later […]
We analyzed illicit drugs and their metabolites and pharmaceuticals in wastewater from 15 selected wastewater treatment plants (WWTPs) in Slovakia. Our results indicate that methamphetamine is one of the most commonly used illegal drugs in all the regions of Slovakia monitored in this study. Compared with the international results, the Slovak cities of Dunajská Streda […]
Rapid identification of drug-type strains in Cannabis sativa using loop-mediated isothermal amplification assay.
In Cannabis sativa L., tetrahydrocannabinol (THC) is the primary psychoactive compound and exists as the carboxylated form, tetrahydrocannabinolic acid (THCA). C. sativa is divided into two strains based on THCA content-THCA-rich (drug-type) strains and THCA-poor (fiber-type) strains. Both strains are prohibited by law in many countries including Japan, whereas the drug-type strains are regulated in […]
Cannabis Use and Associated Harms among Schizophrenia Patients in a Nigerian Clinical Setting: A Case-Control Study.
AIM: The overall aim of this study was to determine the prevalence of cannabis use among patients with schizophrenia with associated levels of harm in a Nigerian clinical setting. METHOD: In this case-control study, consecutive 150 patients with schizophrenia were matched by age and gender with an equal number of patients that utilized the general […]
Age at First Use and Later Substance Use Disorder: Shared Genetic and Environmental Pathways for Nicotine, Alcohol, and Cannabis.
Behavioral genetic studies have provided insights into why early substance use initiation is associated with increased risk for disorder. Few genetically informative studies, however, have operationalized initiation as the of first use and simultaneously modeled the timing of initiation and problematic use of multiple substances. Such research can help capture the risk associated with early […]
Lack of housing, hospital treatment and premature mortality: a cohort study of people in Counties Manukau district.
AIM: We considered risk factors for mortality in people admitted to Counties Manukau inpatient facilities, who were also identified by medical staff to have insufficient housing. METHOD: A cohort study of people aged 15 to 75 years admitted to Counties Manukau inpatient facilities were selected between 2002 and 2014, with ICD-10 codes for insufficient housing. […]
Researchers from Columbia University Medical Center (CUMC) found that men had greater pain relief than women after smoking marijuana. Results of the study were recently published online in Drug and Alcohol Dependence. “These findings come at a time when more people, including women, are turning to the use of medical cannabis for pain relief,” said […]
In the fall of 2013 I began working with Dr. Sue Sisley raising awareness and support for her research studying the safety and efficacy of cannabis when used to treat treatment-resistant post traumatic stress disorder (PTSD). When Dr. Sisley was fired from the University of Arizona we found ourselves abruptly going from a friendly, cooperative […]
Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness.
The physiological activities of cannabidiolic acid (CBDA), a component of fiber-type cannabis plants, have been demonstrated and include its function as a protector against external invasion by inducing cannabinoid-mediated necrosis (Shoyama et al., Plant Signal Behav 3:1111-1112, 2008). The biological activities of CBDA have been attracting increasing attention. We previously identified CBDA as an inhibitor […]
Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: A survey of preferences, attitudes and beliefs among patients willing to consider participation.
BACKGROUND: Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. AIMS: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer. METHODS: A cross-sectional anonymous survey was administered […]
Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol.
BACKGROUND: With the non-medical use of prescription opioids increasingly becoming a method of abuse in Canada, the number of patients requiring methadone maintenance treatment (MMT) for opioid use disorder has increased dramatically. The rate of cannabis use in this population is disproportionately high (~50 %). Because its use is generally perceived as harmless, cannabis use is […]
BACKGROUND: Globally, the most widely used set of compounds among the internationally regulated drugs is cannabis. OBJECTIVE: To review evidence from epidemiological research on cannabis, organized in relation to this field's five main rubrics: quantity, location, causes, mechanisms, and prevention/control. METHOD: The review covers a selection of evidence from standardized population surveys, official statistics, and […]
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.
RATIONALE: AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects. OBJECTIVES: The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 […]
Critical comparison of mass analyzers for forensic hair analysis by ambient ionization mass spectrometry.
RATIONALE: Recently, several direct and/or ambient mass spectrometry (MS) approaches have been suggested for drugs of abuse imaging in hair. The use of mass spectrometers with insufficient selectivity could result in false-positive measurements due to isobaric interferences. Different mass analyzers have been evaluated regarding their selectivity and sensitivity for the detection of Δ9-tetrahydrocannabinol (THC) from […]
Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
IMPORTANCE: Marijuana use is increasingly common in the United States. It is unclear whether it has long-term effects on memory and other domains of cognitive function. OBJECTIVE: To study the association between cumulative lifetime exposure to marijuana use and cognitive performance in middle age. DESIGN, SETTING, AND PARTICIPANTS: We used data from the Coronary Artery […]
Development of a novel immunoassay for herbal cannabis using a new fluorescent antibody probe, “Ultra Quenchbody”.
We developed a novel immunoassay for herbal cannabis based on a new immunoassay principle that uses Ultra Quenchbody (“UQ-body”), a recombinant antibody Fab fragment fluorolabeled at the N-terminal regions. When the antigen binds to anti-Δ9-tetrahydrocannabinol (THC) UQ-body, the fluorescence intensity (FI) decreases. The analytical conditions of the immunoassay were optimized based on the FI reduction […]
Background Cannabis use typically commences during adolescence, a period during which the brain undergoes profound remodeling in areas that are high in cannabinoid receptors and that mediate cognitive control and emotion regulation. It is therefore important to determine the impact of adolescent cannabis use on brain function. Objective We investigate the impact of adolescent cannabis […]
AIMS: To estimate cannabis use disorder (CUD) trajectory classes from ages 14 through 30 and compare classes on clinical characteristics, risk factors, and psychosocial outcomes. DESIGN: Four waves (T1 -T4 ) of data from an epidemiological study of psychopathology among a regionally representative sample. Trajectory classes described risk for CUD as a function of age. […]
BACKGROUND: Incentive salience is a multidimensional construct that includes craving, drug value relative to other reinforcers, and implicit motivation such as attentional bias to drug cues. Laboratory cue reactivity (CR) paradigms have been used to evaluate marijuana incentive salience with measures of craving, but not with behavioral economic measures of marijuana demand or implicit attentional […]
BACKGROUND AND AIMS: While the prevalence of major depression is elevated amongst cannabis users, the role of genetics in this pattern of comorbidity is not clear. This study aimed to estimate the heritability of cannabis use and major depression, quantify the genetic overlap between these two traits, and localize regions of the genome that segregate […]
BACKGROUND: Preclinical studies demonstrate that cannabinoid-mediated antinociceptive effects vary according to sex; it is unknown if these findings extend to humans. METHODS: This retrospective analysis compared the analgesic, subjective and physiological effects of active cannabis (3.56-5.60% THC) and inactive cannabis (0.00% THC) in male (N=21) and female (N=21) cannabis smokers under double-blind, placebo-controlled conditions. Pain […]
BACKGROUND: Substance exposure is thought to contribute to reports of suspected maltreatment made to child protective services (CPS) at or shortly after birth. There are limited data, however, on whether clinicians are more likely to report black and Hispanic substance-exposed infants compared with white infants. METHODS: We examined racial differences in diagnosed substance exposure and […]
Hair analysis and its concordance with self-report for drug users presenting in emergency department.
BACKGROUND: Secondary analysis using data from the National Drug Abuse Treatment Clinical Trials Network randomized trial (NCT # 01207791), in which 1285 adult ED patients endorsing moderate to severe problems related to drug use were recruited from 6 US academic hospitals. OBJECTIVE: To investigate the utility of hair analysis in drug use disorder trials with […]
BACKGROUND: Strategies are needed to identify youth developing schizophrenia. The present study aimed to determine whether adolescents treated for substance misuse were at elevated risk to develop schizophrenia, whether this risk has changed since the late 1960s, and whether substance misuse in adolescence predicted poorer outcomes through adulthood. METHOD: In a Swedish city, since the […]
BACKGROUND: Risky behaviors may interrupt development or cause considerable morbidity or mortality. This study’s purpose was to determine subgroups of students based on risky behaviors and assess the prevalence of risky behaviors in each of the subgroups. PARTICIPANTS AND METHODS: This anonymous cross-sectional study was carried out in October 2015 and November 2015, with 1,777 […]